Cancer Prevention Platform

Cancer is caused by cumulative DNA mutations resulting in eventual expression of one to many oncogenes (over 50 in total) and loss of one to many tumor suppressor genes (including p53, p73...) in the same cell, or cancer cell. Normal cells usually do not express these oncogenes and do not lose any of the tumor suppressor genes. Pre-cancer cells are the intermediates between cancer cells and normal cells. Pre-cancer cells usually express at least one oncogene, but did not lose any tumor suppressor genes or just have lost at least one tumor suppressor gene but did not express any oncogenes yet.

Theoretically, any measure that can prevent DNA mutations, or inactivate cells with oncogene expression or the loss of tumor suppressor genes or both may prevent cancer. Practically however, DNA mutations are caused by so many factors, including but not limited to UV light, microwaves, radiation, free radicals, carcinogens, viruses, bacterial infections and genetic defects, that it is almost impossible to avoid all of them in life time in order to prevent cancer. Thus, avoiding over exposure to UV light, microwaves and radiation, having antioxidants to neutralized free radicals and enhancing immune system to avoid viral and bacterial infections may delay DNA mutations and cancer.

One of the most effective proven ways for disease prevention is the vaccine. A vaccine against a cancer causing viral agent such as human papillomavirus (HPV) can prevent HPV from causing cervical cancer. However, since the so-called HPV cancer vaccine is built against the HPV virus, not the resultant cervical cancer cells, the antiviral HPV vaccine cannot kill already existing cervical cancer cells.

The most advanced strategy to prevent cancer is to mold a patient's immune system at the DNA level to recognize and be immunized against pre-cancer, cancer and cancer stem cells. This is the acquired immunity or anamnestic or secondary immunity that enables the full immune system to kill pre-cancer cells for a long time. BioMedicure's cancer vaccines made out of "solid tumors" grown by enriched cancer stem cells can prevent cancer by killing pre-cancer cells and cancer cells specifically. The whole-cell giant liposome cancer vaccine forces the immune system to compare the content of cancer cells with that of normal cells and renew or build the immune system to recognize pre-cancer, cancer and cancer stem cells and kill them specifically. This strategy fully uses the potential of the immune system to fight against cancer cells and decrease the occurrence or recurrence rates of cancer.

BioMedicure has proven the concept in wild-type animals (NIH Annual Meeting 2009: Frontiers in Basic Immunology poster 51: "Harmless derivatives of cancer cells induced adaptive immune responses against cancer cells") and is looking for partners who are interested in taking CancerVaccine™ to clinical trials to prove the concept clinically in dogs, cats and humans.

BioMedicure is also sharing its proprietary cancer prevention products with cancer researchers. If you are interested in transforming cancer prevention, you can order BioMedicure's products including CancerVaccine™ for your disease of interest.