Cancer Prevention Platform

Cancer is caused by cumulative DNA mutations resulting in eventual expression of one to many oncogenes (over 50 in total) and loss of one to many tumor suppressor genes (including p53, p73...) in the same cell, or cancer cell. Normal cells usually do not express these oncogenes and do not lose any of the tumor suppressor genes. Pre-cancer cells are the intermediates between cancer cells and normal cells. Pre-cancer cells usually express at least one oncogene, but did not lose any tumor suppressor genes or just have lost at least one tumor suppressor gene but did not express any oncogenes yet.

Theoretically, any measure that can prevent DNA mutations, or inactivate cells with oncogene expression or the loss of tumor suppressor genes or both may prevent cancer. Practically however, DNA mutations are caused by so many factors, including but not limited to UV light, microwaves, radiation, free radicals, carcinogens, viruses, bacterial infections and genetic defects, that it is almost impossible to avoid all of them in life time in order to prevent cancer. Thus, avoiding over exposure to UV light, microwaves and radiation, having antioxidants to neutralize free radicals and enhancing immune system to avoid viral and bacterial infections may delay DNA mutations and cancer.

One of the most effective proven ways for disease prevention is the vaccine. A vaccine against a cancer causing viral agent such as human papillomavirus (HPV) can prevent HPV from causing cervical cancer. However, since the so-called HPV cancer vaccine is built against the HPV virus, not the resultant cervical cancer cells, the antiviral HPV vaccine cannot kill already existing cervical cancer cells.

The most advanced strategy to prevent cancer is to transform a patient's immune system with acquired immunity against pre-cancer, cancer and cancer stem cells, just like the way Smallpox, Cowpox or the cervical cancer have been prevented with corresponding viral vaccines. BioMedicure's CancerVaccine™ products (antigen spheres) have been developed using the same principles:

  • They are stable (without apoptosis) derivatives of the "pathogens", cancer cells;
  • They are harmless, non-viable, non-toxic but "foreign" to any lymphocytes in the immune system and the body;
  • They force the immune system to respond immediately and permanently against the antigenic material preserved in the vaccine without any autoimmune disease.

BioMedicure has made the first successful CancerVaccine™ products from cancer cells (CSC-016, BioMedicure) to prevent cancer such as melanoma in wild-type mice (c57). These products have been made using Tumorase™ (US TradeMark 3,795,961) that digests and removes all extracellular proteins without breaking the membrane. Thus, cellular antigen spheres preserving intracellular antigenic material are produced. The separation of antigen spheres with Tumorase™ made the product harmless.

Just like the successful viral vaccines, BioMedicure's CancerVaccine™ products addressed the safety, efficacy, quality control, and ethic issues.

BioMedicure has proven the concept in wild-type animals (NIH Annual Meeting 2009: Frontiers in Basic Immunology poster 51: "Harmless derivatives of cancer cells induced adaptive immune responses against cancer cells") and is looking for partners who are interested in taking CancerVaccine™ to clinical trials to prove the concept clinically in dogs, cats and humans.

BioMedicure is also sharing its proprietary cancer prevention products with cancer researchers. If you are interested in transforming any immune system with cancer vaccine for cancer prevention, you can order BioMedicure's CancerVaccine™ for your disease of interest. From your hands experiments, you will be able to see CancerVaccine™ transformed immune system can kill up to 100% of all cancer cells after a month or months of vaccination and protect the vaccinated individual from cancer for a long time. You will notice that irradiated cancer cells has no effect and irradiated cancer cells with an adjuvant such as GM-CSF or BCG have some effects in killing cancer cells due to delayed type hypersensitive (DTH) responses that may last for days but not a long time.