One type of genetic mutation in enriched cancer stem cells is translocation.

Similar to a deletion, the effect of a translocation depends on which sequence is translocated, how big it is, and how important the coding sequence is. However, differing from a deletion, the translocated sequence does not disappear, it appears somewhere else in the same chromosome or different chromosomes. This will interrupt another sequence of DNA. Again, where the sequence is landed will determine the fate of another gene or genes if they are expressed together. Thus, a single translocation may affect the function of multiple genes. Unlike deletion and duplication, the length of the DNA sequence does not change if the translocation remains within the same gene. However, due to frame shift, malfunction of the gene with translocation is highly likely. If the translocation involved two different genes or chromosomes, multiple genes may be affected.

"Solid tumor" cells grown from enriched cancer stem cells, CancerStemCell™, have all types of mutations, including translations. It is not known what are the translocated DNA sequences or how many translocations occur in a single cancer cell or the heterogeneous population. However, the degree of mutations and number of antigens in the "solid tumor" cells are comparable to that of metastasized tumor cells since the whole cell "giant liposome" cancer vaccines, CancerVaccine™, made out of "solid-tumors" grown from enriched cancer stem cells and metastasized tumor cells have induced similar immune responses.